All COVID mechanisms [update]: how SARS-CoV-2 leads to thrombosis, endotheliopathy and hypercoagulation with subsequent neuro-COVID
Originally published: 9 January 2021 A comprehensive clinical picture of COVID-19: inflammation, coagulation, endotheliopathy and thrombosis By: Mercedes Bouter Mechanisms of COVID: inflammation/cytokine cascade, thrombotic and fibrotic cascade, sepsis and endotheliopathy as key events. Review, text and graphic design by Mercedes Bouter The one question of the COVID-19 pandemic is: Why are thrombosis and thromboembolism persistent, in spite of adequate thromboprophylaxis and anticoagulation? The answer is: endothelial damage is a major factor that keeps on driving thrombotic events. Meanwhile, the practice of prophylactic and therapeutic doses of anticoagulation to treat COVID thromboembolism might have actually been inadequate (see " A remaining challenge: hypercoagulability characterizing COVID-19, despite anticoagulation practices ", 5 Oktober 2020, " A stubborn complication: the quest for solutions to COVID's thrombosis pandemic ", 30
